Initial release of [3H]dopamine from rat striatal synaptosomes: correlation with calcium entry
نویسندگان
چکیده
منابع مشابه
Initial release of [3H]dopamine from rat striatal synaptosomes: correlation with calcium entry.
Calcium entry and dopamine (DA) release were compared in rat striatal synaptosomes, to evaluate the role of Ca in mammalian CNS presynaptic neurotransmission. After equilibrating the synaptosomes with 0.1 PM [“HIDA, release was measured at O.l-min intervals by collecting superfusion effluents; release was measured over lto lo-set intervals by a novel rapid filtration technique in which release ...
متن کاملRelease of dopamine from striatal synaptosomes.
The mechanisms of dopamine (DA) release central nerve endings have been investigated utilizing superfused rat striatal synaptosomes. Nomifensine was selected as a tool to discriminate between release mediated by the DA carrier and release occurring independently of the carrier. The following conclusions can be drawn from the results obtained: 1) Alterations of the sodium gradient across the syn...
متن کاملEffect of Novel -Conotoxins on Nicotine-Stimulated [H]Dopamine Release from Rat Striatal Synaptosomes
Nicotine’s action on the midbrain dopaminergic neurons is mediated by nicotinic acetylcholine receptors (nAChRs) that are present on the cell bodies and the terminals of these neurons. Previously, it was suggested that one of the nAChR subtypes located on striatal dopaminergic terminals may be an 3 2 subtype, based on partial inhibition of nicotine-stimulated [H]dopamine release by -conotoxin M...
متن کاملNon-cholinergic effects of paraoxon on [3h]-GABA release from rat cerebellar giant synaptosomes
Diethyl p-nitrophenyl phosphate (paraoxon) is the active toxic metabolite of parathion. Some evidences indicate that OPs affect the GABA system via noncholinergic mechanisms. The purpose of this study was to investigate the effects of paraoxon on K+-evoked [3H]-GABA release from cerebellar synaptosomes. Adult male rats (200 ± 30 g; 3-4 months old) were sacrificed by decapitation and the cerebel...
متن کاملNon-cholinergic effects of paraoxon on [3h]-GABA release from rat cerebellar giant synaptosomes
Diethyl p-nitrophenyl phosphate (paraoxon) is the active toxic metabolite of parathion. Some evidences indicate that OPs affect the GABA system via noncholinergic mechanisms. The purpose of this study was to investigate the effects of paraoxon on K+-evoked [3H]-GABA release from cerebellar synaptosomes. Adult male rats (200 ± 30 g; 3-4 months old) were sacrificed by decapitation and the cerebel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1983
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.03-04-00703.1983